Cerebrospinal Fluid Analysis in Immunoglobulin G4-related Hypertrophic Pachymeningitis

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Cerebrospinal fluid analysis in immunoglobulin G4-related hypertrophic pachymeningitis.

Volume 40, no. 11 Pachymeningitis Cerebrospinal Fluid Analysis in Immunoglobulin G4-related Hypertrophic ELISABETTA ZARDINI, MARIA GRAZIA SABBADINI and DIEGO FRANCIOTTA ROVERI, RAFFAELLA CHIEFFO, NICOLETTA ANZALONE, CLAUDIO DOGLIONI, EMANUEL DELLA-TORRE, GABRIELLA PASSERINI, ROBERTO FURLAN, LUISA http://www.jrheum.org/content/40/11/1927 J Rheumatol 2013;40;1927-1929 http://www.jrheum.org/alerts...

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Immunoglobulin G4-Related Hypertrophic Pachymeningitis Mimicking Chiari Malformation.

Dear Editor, Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized clinical entity characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells leading to organ swelling or sclerosis.1 IgG4-RD may affect various organs, more commonly the orbit or pituitary gland than the nervous system. However, due to increasing reports on meningeal inflammation associated...

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Immunoglobulin G4-Related Hypertrophic Pachymeningitis with Skull Involvement

Immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis, defined as focally or diffusely thickened dura mater and lymphoplasmacytic infiltration with increased IgG4 bearing plasma cells, is a rare disease. Moreover, cases involving bone are even rarer. In this report, the authors describe a case of IgG4-related hypertrophic pachymeningitis involving the skull in a 65-year-old man presenti...

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Immunoglobulin G4 and related diseases.

i mmunoglobulins, produced by plasma cells, are the effector arm of the humoral immune system [1]. Each immunoglobulin consists of two identical heavy chains (α, β, γ, δ or ε – all encoded by chromosome 14) and two identical light chains (either κ or λ, encoded by chromosome 2 and 22, respectively) [2]. The immunoglobulins have constant (C) regions (similar within the same isotype) and variable...

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IgG4-Related Disease and Hypertrophic Pachymeningitis

Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result from mass effect, nerve compression, or vascular compromise. The differential diagnosis of HP includes immune-mediated conditions such as rheumatoid arthritis and vasculitis, malignancies, and infections. Many times, no diagnosis is re...

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ژورنال

عنوان ژورنال: The Journal of Rheumatology

سال: 2013

ISSN: 0315-162X,1499-2752

DOI: 10.3899/jrheum.130678